The NovaSeq X Plus, a cutting-edge DNA sequencer, boosts ELIXIR-IT's research capacity, allowing over 100 human genome sequences in 48 hours, solidifying our leadership in genomics and bioinformatics.
ELIXIR-STEERS, a new EU-funded project, will enhance federated data analysis in life sciences across Europe. The project focuses on improving software and workflows to increase efficiency, reduce duplication, and lower the carbon footprint of computational research.
The EU's "Genome Data Infrastructure" (GDI) project will create a system for sharing genomic and clinical data for precision medicine, with Italy participating.
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ELIXIRxNextGenIT will expand Italy's 'Omics and Bioinformatics' infrastructure. It aims to enhance ELIXIR-IT's services, including creating a Federated European Genome-phenome Archive.
CREDO, a Customizable, REproducible, DOcker file generator for bioinformatics applications, has been developed as a tool to moderate reproducibility issues by building and distributing docker containers with embedded bioinformatics tools. CREDO simplifies the process of generating Docker images, facilitating reproducibility and efficient research in bioinformatics.
In this work, it is evaluated the possibility of improving AlphaFold2’s three-dimensional predictions by developing a new pipeline (AlphaMod) that integrates AlphaFold2 with MODELLER, a traditional homology modeling program. For this study, MARCONI100 at HPC@CINECA was used, which was made available through an ELIXIR project.
In this study, we explored the link between gut impairment and severe COVID-19 in people with HIV (PWH). We compared PWH with COVID-19 to HIV-uninfected individuals hospitalized for the same condition. Despite more severe clinical symptoms in PWH, we did not observe significant differences in gut barrier dysfunction markers between the two groups.
Recent years have seen a substantial increase in RNA-seq data production, with this technique becoming the primary approach for gene expression studies across a wide range of non-model organisms. The majority of these organisms lack a well-annotated reference genome to serve as a basis for studying differentially expressed genes (DEGs).