ELIXIRxNextGenIT will expand Italy's 'Omics and Bioinformatics' infrastructure. It aims to enhance ELIXIR-IT's services, including creating a Federated European Genome-phenome Archive.
Protein embeddings encode sequence information using protein language models. The Embedding-Based Alignment (EBA) method enables pairwise embedding comparison and remote homolog detection. In this paper we show that, when applied to a set of multifunctional human proteins, EBA identifies remote homologs sharing structural and functional features, validated on the Swiss-Prot database.
CREDO, a Customizable, REproducible, DOcker file generator for bioinformatics applications, has been developed as a tool to moderate reproducibility issues by building and distributing docker containers with embedded bioinformatics tools. CREDO simplifies the process of generating Docker images, facilitating reproducibility and efficient research in bioinformatics.
In this work, it is evaluated the possibility of improving AlphaFold2’s three-dimensional predictions by developing a new pipeline (AlphaMod) that integrates AlphaFold2 with MODELLER, a traditional homology modeling program. For this study, MARCONI100 at HPC@CINECA was used, which was made available through an ELIXIR project.
In this study, we explored the link between gut impairment and severe COVID-19 in people with HIV (PWH). We compared PWH with COVID-19 to HIV-uninfected individuals hospitalized for the same condition. Despite more severe clinical symptoms in PWH, we did not observe significant differences in gut barrier dysfunction markers between the two groups.